We    also   showed

that the BCL10-SQSTM1 interaction is

crucial for TCR signaling to IKBK and

consequent activation of NFKB1-RELA.

Importantly,  we  found  that  SQSTM1

speckles   simultaneously   interact   with

BCL10    and    LC3+        autophagosomes.

The   SQSTM1-LC3   interaction   results

in  autophagic  uptake  and  degradation

of   SQSTM1-bound    BCL10,    thereby

depleting   the   active   polyubiquitinated

form of BCL10 and limiting the magni-