Abstract

In the past 10 years, autophagy has emerged as a crucial regulator of T-cell homeostasis, activation and differentiation. Through the ability to adjust the cell’s proteomein response to different

stimuli, different forms of autophagy have been shown to control T-cell homeostasis and survival.

Autophagic processes can also determine the magnitude of the T-cell response to TCR

engagement,by regulating the cellular levels of specific signaling intermediates and modulating the metabolic output in activated T-cells. In this review we will examine the mechanisms that

control autophagy activity in T-cells, such as ROS signaling and signaling through common

gamma-chain cytokine receptors, and the different aspect of T-cell biology, including,