Chaperone-mediated autophagy in T-cells

The remarkable specificity of CMA for specific cytosolic proteins is achieved by the

cooperative activity of the molecules LAMP-2A and Hsc70 [64, 65]. The CMA-targeted

pool of protein substrates, bear one or more consensus motifs biochemically related to the

pentapeptide KERFQ, which is recognized by Hsc70 within a particular cytosolic chaperone complex (reviewed in [66], Figure 2). This chaperone complex brings the substrates to the