However, stressors, such as oxidative stress, may induce transcriptional upregulation of

Lamp2a expression, to increase the presence of LAMP-2A at the lysosomal membrane [70].

Our laboratory has recently has recently shown that CMA regulates CD4+ T-cell responses    through the targeted degradation of negative regulatorsofTCR signaling, such as Rcan1 and

Itch [71]. CMA is activated in response to engagement of the TCR, which induces