conserved transcription factor that regulates an ever-expanding network of genes with a wide range of functions in cell survival, diferentiation, proliferation, and immunity, acting downstream TLRs and cytokine receptors. Studies have demonstrated that, following  activation  of  NF-κB,   autophagy  plays   a  role  in the  degradation  of  the  NF-κB  inhibitor  family  IκB, leading to  persistent  activation  and  inlammation  (51 ).  Additionally, autophagy inhibits inlammasome activation and IL-1β release by stimulated