responses. A data search was conducted using Pubpkd and included studies published through November 1, 2017. Search terms used include cancer immunotherapy, pembrolizumab, ipilimumab, nivolumab, PD-1 inhibitors, PD-L1 inhibitors, checkpoint inhibitors, anticancer

vaccines, TVEC, and adoptive cell therapy.The advances in cancer immunotherapy copk with several oadtacles, limiting its widespread use and benefits so far only to a small suadet of